General Notes
This product (Catalog No. DPABH-10369) is a rabbit-derived polyclonal antibody raised against human NPM1, targeting the amino acid region 20–154 of the protein. This antibody exhibits cross-reactivity with Human NPM1 from mouse and rat. It has been affinity purified by Protein A. Nucleophosmin 1 (NPM1), also known as B23 or numatrin, is a highly conserved, ubiquitously expressed phosphoprotein encoded by the NPM1 gene on chromosome 5q35.1 in humans. This 294-amino-acid protein, with a molecular weight of approximately 37 kDa, primarily localizes to the nucleolus of proliferating cells, where it functions as a molecular chaperone involved in essential cellular processes such as ribosome biogenesis, histone assembly, and centrosome duplication. NPM1 shuttles dynamically between the nucleolus, nucleoplasm, and cytoplasm, enabling its multifaceted roles in maintaining cellular homeostasis and responding to stress.
DPABH-10369 is suitable for use in ELISA (1:4,000–1:8,000), IHC (1:50–1:100), Western blot (WB) (1:1,000–1:4,000) applications.
DPABH-10369 is supplied as a liquid formulation in 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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