Anti-NPFF monoclonal antibody (DCABH-12604) Made to order

Rabbit anti-Human NPFF monoclonal antibody for WB, ELISA

View other NPFF antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human NPFF is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
NPFF; neuropeptide FF-amide peptide precursor; FMRFamide-related peptides; FMRFAL
Entrez Gene ID
UniProt ID

Product Background


Gene summary
NPFF (Neuropeptide FF-Amide Peptide Precursor) is a Protein Coding gene. Diseases associated with NPFF include pain agnosia and agnosia. Among its related pathways are Signaling by GPCR and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include receptor binding and neuropeptide hormone activity. This gene encodes a member of the FMRFamide related peptide (FARP) family of neuropeptides. The encoded preproprotein is proteolytically processed to generate multiple amidated peptides. These peptides may play a role in the regulation of heart rate and blood pressure and the modulation of morphine-induced antinociception. Patients with hypertension exhibit decreased expression of the encoded protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
Antigen Description
FMFRamide-related protein precursor plays a role in the regulation of heart rate and blood pressure and the modulation of morphine-induced antinociception. FMRFAL encodes a preproprotein which is cleaved to form two active peptides with similar function. Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. Neuropeptide FF potentiates and sensitizes ASIC1 and ASIC3 channels. NPFF Neuropeptide FF (FLFQPQRFa) is a mammalian amidated neuropeptide originally isolated from bovine brain and characterized as a pain-modulating peptide, with anti-opioid activity on morphine-induced analgesia. 0The function about NPFF antigen include neuropeptide hormone activity; receptor binding.
Pathway
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; Orexin and neuropeptides FF and QRFP bind to their respective receptors, organism-specific biosystem; Peptide ligand-binding receptors, organism-specific biosystem; Signal Transduction, organism-specific biosystem.

Citations


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We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Sol, JC; Roussin, A; et al. Enzymatic degradation of neuropeptide FF and SQA-neuropeptide FF in the mouse brain. PEPTIDES 20:1219-1227(1999).
Chen, JC; Li, JY; et al. Neuropeptide FF potentiates the behavioral sensitization to amphetamine and alters the levels of neurotransmitters in the medial prefrontal cortex. BRAIN RESEARCH 816:220-224(1999).

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