Anti-PNP monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide of human NP is used for rabbit immunization.

Conjugate

Alternative Names

PNP; purine nucleoside phosphorylase; NP; PUNP; PRO1837; HEL-S-156an; inosine phosphorylase; inosine-guanosine phosphorylase; epididymis secretory sperm binding protein Li 156an; purine-nucleoside:orthophosphate ribosyltransferase;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes an enzyme which reversibly catalyzes the phosphorolysis of purine nucleosides. The enzyme is trimeric, containing three identical subunits. Mutations which result in nucleoside phosphorylase deficiency result in defective T-cell (cell-mediated) immunity but can also affect B-cell immunity and antibody responses. Neurologic disorders may also be apparent in patients with immune defects. A known polymorphism at aa position 51 that does not affect enzyme activity has been described. A pseudogene has been identified on chromosome 2.

Pathway

Metabolism; Metabolism of nucleotides;Nicotinate and nicotinamide metabolism;Purine metabolism; Purine salvage; Pyrimidine metabolism; adenine and adenosine salvage III; adenine and adenosine salvage III; adenosine nucleotides degradation; adenosine nucleotides degradation II; arsenate detoxification I (glutaredoxin);