Anti-NNMT monoclonal antibody (DCABH-771)

Mouse anti-Human NNMT monoclonal antibody for WB, IHC-P, FC Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
4F4
Species Reactivity
Human
Immunogen
Recombinant full length Human NNMT produced in HEK293T cells (NP_006160).
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/2000; IHC-P: 1/150; Flow Cyt: 1/100;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
NNMT; nicotinamide N-methyltransferase
Entrez Gene ID
UniProt ID

Product Background


Gene summary
NNMT (Nicotinamide N-Methyltransferase) is a Protein Coding gene. Diseases associated with NNMT include parkinson disease, late-onset. Among its related pathways are Metabolism and Phase II conjugation. GO annotations related to this gene include methyltransferase activity and nicotinamide N-methyltransferase activity. An important paralog of this gene is PNMT. N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. This gene encodes the protein responsible for this enzymatic activity which uses S-adenosyl methionine as the methyl donor.
Antigen Description
Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds. Nicotinamide N-methyltransferase is an enzyme that in humans is encoded by the NNMT gene. 0The function about NNMT antigen include methyltransferase activity; nicotinamide N-methyltransferase activity; transferase activity.
Pathway
Biological oxidations, organism-specific biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Methylation, organism-specific biosystem; Nicotinate and nicotinamide metabolism, organism-specific biosystem; Nicotinate and nicotinamide metabolism, conserved biosystem; Phase II conjugation, organism-specific biosystem.

Citations


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References


Katayama, K; Sasaki, T; et al. Insertional mutation in the Golgb1 gene is associated with osteochondrodysplasia and systemic edema in the OCD rat. BONE 49:1027-1036(2011).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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