Anti-NLRP7 polyclonal antibody (DPABH-23051)

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
Recombinant fragment, corresponding to a region within amino acids 454-635 of Human NLRP7 (Q8WX94).
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/500 - 1/3000.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
NLRP7; NLR family, pyrin domain containing 7; NACHT, leucine rich repeat and PYD containing 7; NALP7; NACHT, LRR and PYD domains-containing protein 7; CLR19.4
Entrez Gene ID
UniProt ID

Product Background


Gene summary
NLRP7 (NLR Family, Pyrin Domain Containing 7) is a Protein Coding gene. Diseases associated with NLRP7 include hydatidiform mole, recurrent, 1 and partial hydatidiform mole. Among its related pathways are Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways and Toll-Like receptor Signaling Pathways. An important paralog of this gene is NLRP14. This gene encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. This gene may act as a feedback regulator of caspase-1-dependent interleukin 1-beta secretion. Alternative splicing results in multiple transcript variants encoding different isoforms.
Antigen Description
Inhibits CASP1/caspase-1-dependent IL1B secretion. Hydatidiform mole, recurrent, 1 (HYDM1) [MIM:231090]: A disorder characterized by excessive trophoblast development that produces a growing mass of tissue inside the uterus at the beginning of a pregnancy. It leads to abnormal pregnancies with no embryo, and cystic degeneration of the chorionic villi. Note=The disease is caused by mutations affecting the gene represented in this entry. NACHT, LRR and PYD domains-containing protein 7 is a protein that in humans is encoded by the NLRP7 gene. NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP7, have an N-terminal pyrin (MEFV) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NALPs are implicated in the activation of proinflammatory caspases (e. g. , CASP1) via their involvement in multiprotein complexes called inflammasomes. The function about NLRP7 antigen include ATP binding; nucleotide binding.

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Akoury, E; Zhang, L; et al. NLRP7 and KHDC3L, the two maternal-effect proteins responsible for recurrent hydatidiform moles, co-localize to the oocyte cytoskeleton. HUMAN REPRODUCTION 30:159-169(2015).

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