Anti-NLRC4 (C-terminal) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

a synthetic peptide corresponding to amino acids near the C-terminus of human Ipaf.

Conjugate

Alternative Names

NLRC4; NLR family, CARD domain containing 4; CLAN; IPAF; CLAN1; CLANA; CLANB; CLANC; CLAND; CARD12; CLR2.1; NLR family CARD domain-containing protein 4; NOD-like receptor C4; ICE-protease activating factor; ice protease-activating factor; CARD, LRR, and N

Entrez Gene ID

UniProt ID

Antigen Description

In C. elegans, Ced4 binds and activates Ced3, an apoptotic initiator caspase, via caspase-associated recruitment domains (CARDs). Human Ced4 homologs include APAF1 (MIM 602233), NOD1/CARD4 (MIM 605980), and NOD2/CARD15 (MIM 605956). These proteins have at least 1 N-terminal CARD domain followed by a centrally located nucleotide-binding domain (NBD or NACHT) and a C-terminal regulatory domain, found only in mammals, that contains either WD40 repeats or leucine-rich repeats (LRRs). CARD12 is a member of the Ced4 family and can induce apoptosis.[supplied by OMIM, Mar 2008]

Pathway

Direct p53 effectors; Immune System; Inflammasomes; Innate Immune System; Legionellosis; NOD pathway; NOD-like receptor signaling pathway; Nucleotide-binding domain