Anti-NLK monoclonal antibody, clone FQS3123(3)

Antibody Isotype

IgG

Clone

FQS3123(3)

Species Reactivity

Human

Immunogen

Synthetic peptide corresponding to amino acids within Human NLK

Conjugate

Application Notes

WB: 1/1000 - 1/10000; Flow Cyt: 1/10 - 1/100.

Alternative Names

NLK; nemo-like kinase; nemo like kinase; serine/threonine-protein kinase NLK; FLJ21033; DKFZp761G1211;

Entrez Gene ID

UniProt ID

Antigen Description

Role in cell fate determination, required for differentiation of bone marrow stromal cells. Acts downstream of MAP3K7 and HIPK2 to negatively regulate the canonical Wnt/beta-catenin signaling pathway and the phosphorylation and destruction of the MYB transcription factor. May suppress a wide range of transcription factors by phosphorylation of the coactivator, CREBBP (By similarity). Involved in TGFbeta-mediated mesoderm induction, acting downstream of MAP3K7/TAK1 to phosphorylate STAT3.

Pathway

Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; C-MYB transcription factor network, organism-specific biosystem; IL-6 Signaling Pathway, organism-specific biosystem; MAPK signaling pathway, organism-specific biosystem; MAPK signaling pathway, organism-specific biosystem; MAPK signaling pathway, conserved biosystem;