Anti-NEK11 monoclonal antibody (DCABH-930)

Mouse anti-Human NEK11 monoclonal antibody for WB, FC Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
6F0
Species Reactivity
Human
Immunogen
Recombinant full length Human NEK11 produced in HEK293T cells (NP_079076).
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/2000; Flow Cyt: 1/100;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
NEK11; NIMA (never in mitosis gene a)- related kinase 11; serine/threonine-protein kinase Nek11; FLJ23495
Entrez Gene ID
UniProt ID

Product Background


Gene summary
NEK11 (NIMA Related Kinase 11) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is NEK2. This gene encodes a member of the never in mitosis gene A family of kinases. The encoded protein localizes to the nucleoli, and may function with NEK2A in the S-phase checkpoint. The encoded protein appears to play roles in DNA replication and response to genotoxic stress. Alternatively spliced transcript variants have been described.
Antigen Description
Possible role in S-phase checkpoint mechanism. Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation. The function about NEK11 antigen include ATP binding; metal ion binding; nucleotide binding; protein binding; protein serine/threonine kinase activity.

Citations


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References


Melixetian, M; Klein, DK; et al. NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint. NATURE CELL BIOLOGY 11:1247-U212(2009).
Bowers, AJ; Boylan, JF; et al. Nek8, a NIMA family kinase member, is overexpressed in primary human breast tumors. GENE 328:135-142(2004).

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