Fusion protein, corresponding to N terminal amino acids 1-143 of Human Necdin.
Conjugate
Unconjugated
Applications
Application Notes
WB: 1 μg/ml
Target
Alternative Names
NDFIP2; Nedd4 family interacting protein 2; NEDD4 family-interacting protein 2; KIAA1165; N4wbp5a; NEDD4 WW domain binding protein 5A; NEDD4 WW domain-binding protein 5A; NFIP2_HUMAN; Putative MAPK activating protein PM04/PM05/PM06/PM07; Putative MAPK-activating protein PM04/PM05/PM06/PM07
Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle-promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Functions also as transcription factor and binds directly to specific guanosine-rich DNA sequences.
Pathway
Adipogenesis;
Citations
Publication ()
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