Specifications
Immunogen
Synthetic peptide corresponding to residues in Human Nicastrin.
Applications
Application Notes
WB: 1/1000 - 1/10000; ICC: 1/100 - 1/250;
Target
Alternative Names
NCSTN; nicastrin; APH2; KIAA0253; ATAG1874; anterior pharynx-defective 2; RP11-517F10.1;
Product Background
Antigen Description
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.
Pathway
Activated NOTCH1 Transmits Signal to the Nucleus, organism-specific biosystem; Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystem; Delta-Notch Signaling Pathway, organism-specific biosystem; NRIF signals cell death from the nucleus, organism-specific biosystem; Notch signaling pathway, organism-specific biosystem.
Citations
Publication ()
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COA
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