Anti-N. meningitidis Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

N. meningitidis

Immunogen

Whole cell preparation of N. meningitidis types A, B and C

Conjugate

Alternative Names

N meningitides; Neisseria meningitidis; Bacteria; Proteobacteria; Beta Proteobacteria; Neisseriales; Neisseriaceae; Neisseria; N. meningitidis

Antigen Description

Serogroups, A, B, C, D, X, Y, Z, 29E and W135 are responsible for virtually all cases of the human disease.The carbohydrate component of the capsular membrane induces a T cell independent immune response, so neither long term immunity by memory cell formation nor antibody affinity maturation is observed. Rather than being engulfed and processed by an antigen presenting cell, the carbohydrate capsule interacts directly with B cells. This interaction causes production of serogroup specific antibodies, primarily IgM. IgG is also produced with an IgG1 response predominating in children and an IgG2 response predominating in adults.