Anti-Myelin monoclonal antibody (DMAB14435)

Mouse anti-Human Myelin monoclonal antibody for IHC Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgM
Clone
3C6
Species Reactivity
Human
Immunogen
Native purified human Myelin.
Conjugate
Unconjugated

Applications


Application Notes
Immunohistochemistry (1:10) & The optimal working dilution should be determined by the end user.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
MOG; MOG IG 2; Myelin oligodendrocyte glycoprotein CD34(Endothelial Cell Marker); Anti-Myelin Mab; Mouse Anti-Human Myelin Monoclonal Antibody

Product Background


Antigen Description
Myelin is a dielectric (electrically insulating) material that forms a layer, the myelin sheath, usually around only the axon of a neuron. It is essential for the proper functioning of the nervous system. Myelin is an outgrowth of a type of glial cell. The production of the myelin sheath is called myelination. In humans, the production of myelin begins in the fourteenth week of fetal development, although little myelin exists in the brain at the time of birth. During infancy, myelination occurs quickly and continues through the adolescent stages of life.

Citations


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References


Dobolyi, A; Bago, AG; et al. Localization of SUCLA2 and SUCLG2 subunits of succinyl CoA ligase within the cerebral cortex suggests the absence of matrix substrate-level phosphorylation in glial cells of the human brain. JOURNAL OF BIOENERGETICS AND BIOMEMBRANES 47:33-41(2015).
Geis, C; Ritter, C; et al. The intrinsic pathogenic role of autoantibodies to aquaporin 4 mediating spinal cord disease in a rat passive-transfer model. EXPERIMENTAL NEUROLOGY 265:8-21(2015).

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