Anti-IL10RA monoclonal antibody (CABT-33586RM)

Rat anti-Mouse IL10RA monoclonal antibody for FC Datasheet

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Specifications


Host Species
Rat
Antibody Isotype
IgG1
Clone
2C2.4b
Species Reactivity
Mouse
Immunogen
Purified recombinant extracellular region of mouse IL10RA.
Conjugate
Unconjugated

Applications


Application Notes
Flow Cyt: 1/10 - 1/100
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
IL10RA; interleukin 10 receptor, alpha; interleukin-10 receptor subunit alpha; CD210; CDW210A; CDw210a antigen
Entrez Gene ID
UniProt ID

Product Background


Gene summary
IL10RA (Interleukin 10 Receptor Subunit Alpha) is a Protein Coding gene. Diseases associated with IL10RA include inflammatory bowel disease 28, early onset, autosomal recessive and giant cell myocarditis. Among its related pathways are ERK Signaling and Akt Signaling. GO annotations related to this gene include signal transducer activity and interleukin-10 receptor activity. The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene.
Antigen Description
The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression anInflammatory bowel disease 28 (IBD28) [MIM:613148]: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. Note=The disease is caused by mutations affecting the gene represented in this entry. Interleukin 10 receptor, alpha subunit is a subunit for the interleukin-10 receptor. IL10RA, is its human gene. The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. The function about IL10RA antigen include receptor activity.
Pathway
Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Jak-STAT signaling pathway, organism-specific biosystem; Jak-STAT signaling pathway, conserved biosystem; Toxoplasmosis, organism-specific biosystem; Toxoplasmosis, conserved biosystem; Tuberculosis, organism-specific biosystem; Tuberculosis, conserved biosystem.

Citations


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References


Tseng, FC; Brown, EE; et al. Polymorphisms in cytokine genes and risk of Helicobacter pylori infection among jamaican children. HELICOBACTER 11:425-430(2006).
Salzer, U; Neumann, C; et al. Screening of functional and positional candidate genes in families with common variable immunodeficiency. BMC IMMUNOLOGY 9:-(2008).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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