Anti-Medium T monoclonal antibody (DMAB12424)

Rat anti-Virus Medium T monoclonal antibody for WB, IHC, IP Datasheet

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Specifications


Host Species
Rat
Antibody Isotype
IgG2b
Clone
QzNU
Species Reactivity
Mouse
Immunogen
A synthetic peptide corresponding to N-terminus of Polyoma virus, Medium T antigen.
Conjugate
Unconjugated

Target


Alternative Names
Middle t antigen antibody; MPyVgp2 antibody; MT AG antibody; MT antibody; Polyoma virus middle t antigen antibody; Polyomavirus medium t antigen antibody

Product Background


Antigen Description
Middle T antigen (MT) is a 421-amino-acid protein associated with membranes and underlying cytoskeletal elements, and is associated with a tyrosine-specific protein kinase activity. It is the principal oncoprotein of polyomavirus that is necessary and often sufficient for transformation in vitro. MT delivered as a transgene or a retrovirus can induce tumors in a wide variety of tissues. Polyomavirus (PyV) is a small, double-stranded, closed-circular-DNA virus with an approximately 5-kb genome divided into two roughly equal regions. The late transcripts produce the viral capsid proteins, whereas the early region encodes three so-called tumor (T) antigens that are important for both productive infection and transformation.

Citations


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References


Wang, CW; Hillsamer, P; et al. Phenotype, effector function, and tissue localization of PD-1-expressing human follicular helper T cell subsets. BMC IMMUNOLOGY 12:-(2011).
Hu, MH; Zheng, QF; et al. Neuroprotection effect of interleukin ( IL)-17 secreted by reactive astrocytes is emerged from a high-level IL-(17)-containing environment during acute neuroinflammation. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 175:268-284(2014).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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