Anti-Medium T monoclonal antibody (DMAB12424)

Rat anti-Virus Medium T monoclonal antibody for WB, IHC, IP Datasheet

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Specifications


Host Species
Rat
Antibody Isotype
IgG2b
Clone
QzNU
Species Reactivity
Mouse
Immunogen
A synthetic peptide corresponding to N-terminus of Polyoma virus, Medium T antigen.
Conjugate
Unconjugated

Target


Alternative Names
Middle t antigen antibody; MPyVgp2 antibody; MT AG antibody; MT antibody; Polyoma virus middle t antigen antibody; Polyomavirus medium t antigen antibody

Product Background


Antigen Description
Middle T antigen (MT) is a 421-amino-acid protein associated with membranes and underlying cytoskeletal elements, and is associated with a tyrosine-specific protein kinase activity. It is the principal oncoprotein of polyomavirus that is necessary and often sufficient for transformation in vitro. MT delivered as a transgene or a retrovirus can induce tumors in a wide variety of tissues. Polyomavirus (PyV) is a small, double-stranded, closed-circular-DNA virus with an approximately 5-kb genome divided into two roughly equal regions. The late transcripts produce the viral capsid proteins, whereas the early region encodes three so-called tumor (T) antigens that are important for both productive infection and transformation.

Citations


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References


Czajczynska, A; Gunther, A; et al. Allogeneic Stem Cell Transplantation with BEAM and Alemtuzumab Conditioning Immediately after Remission Induction Has Curative Potential in Advanced T-Cell Non-Hodgkin's Lymphoma. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION 19:1632-1637(2013).
Lu, YJ; Yadav, P; et al. Options for Inactivation, Adjuvant, and Route of Topical Administration of a Killed, Unencapsulated Pneumococcal Whole-Cell Vaccine. CLINICAL AND VACCINE IMMUNOLOGY 17:1005-1012(2010).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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