Anti-Macrophage marker monoclonal antibody (DMAB14252)

Mouse anti-Human Macrophage marker monoclonal antibody for IHC Datasheet

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Host Species
Antibody Isotype
Species Reactivity
Native purified from fragments of human spleen depleted of lymphocytes and erythrocytes.


Application Notes
Immunohistochemistry (1:20) & The optimal working dilution should be determined by the end user.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.


Alternative Names
Macrophages; Mouse Anti-Macrophage marker Monoclonal Antibody; Anti-Macrophage marker Monoclonal Antibody; Macrophage marker Monoclonal Antibody Mouse Anti-Macrophage marker MAb; Anti-Macrophage marker MAb; Macrophage marker MAb

Product Background

Antigen Description
Macrophages are cells produced by the differentiation of monocytes in tissues. Macrophages were discovered by Ilya Mechnikov, a Russian bacteriologist, in 1884. Human macrophages are about 21 micrometres (0. 00083 in) in diameter. Monocytes and macrophages are phagocytes. Macrophages function in both non-specific defense (innate immunity) as well as help initiate specific defense mechanisms (adaptive immunity) of vertebrate animals. Their role is to phagocytose, or engulf and then digest, cellular debris and pathogens, either as stationary or as mobile cells. They also stimulate lymphocytes and other immune cells to respond to pathogens. They are specialized phagocytic cells that attack foreign substances, infectious microbes and cancer cells through destruction and ingestion. Macrophages can be identified by specific expression of a number of proteins including CD14, CD40, CD11b, F4/80 (mice)/EMR1 (human), lysozyme M, MAC-1/MAC-3 and CD68 by flow cytometry or immunohistochemical staining. They move by action of amoeboid movement.


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Zhang, C; Liang, T; et al. Evaluation of macrophage migration inhibitory factor as an imaging marker for hepatocellular carcinoma in murine models. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY 46:720-726(2011).
Lee, CW; Hwang, I; et al. Comparison of ADAMTS-1,-4 and -5 expression in culprit plaques between acute myocardial infarction and stable angina. JOURNAL OF CLINICAL PATHOLOGY 64:399-404(2011).

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We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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