Anti-Macrophage marker monoclonal antibody (DMAB14252)

Mouse anti-Human Macrophage marker monoclonal antibody for IHC Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2b
Clone
4B6
Species Reactivity
Human
Immunogen
Native purified from fragments of human spleen depleted of lymphocytes and erythrocytes.
Conjugate
Unconjugated

Applications


Application Notes
Immunohistochemistry (1:20) & The optimal working dilution should be determined by the end user.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
Macrophages; Mouse Anti-Macrophage marker Monoclonal Antibody; Anti-Macrophage marker Monoclonal Antibody; Macrophage marker Monoclonal Antibody Mouse Anti-Macrophage marker MAb; Anti-Macrophage marker MAb; Macrophage marker MAb

Product Background


Antigen Description
Macrophages are cells produced by the differentiation of monocytes in tissues. Macrophages were discovered by Ilya Mechnikov, a Russian bacteriologist, in 1884. Human macrophages are about 21 micrometres (0. 00083 in) in diameter. Monocytes and macrophages are phagocytes. Macrophages function in both non-specific defense (innate immunity) as well as help initiate specific defense mechanisms (adaptive immunity) of vertebrate animals. Their role is to phagocytose, or engulf and then digest, cellular debris and pathogens, either as stationary or as mobile cells. They also stimulate lymphocytes and other immune cells to respond to pathogens. They are specialized phagocytic cells that attack foreign substances, infectious microbes and cancer cells through destruction and ingestion. Macrophages can be identified by specific expression of a number of proteins including CD14, CD40, CD11b, F4/80 (mice)/EMR1 (human), lysozyme M, MAC-1/MAC-3 and CD68 by flow cytometry or immunohistochemical staining. They move by action of amoeboid movement.

Citations


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References


Kimura, K; Kitaura, H; et al. Anti-c-Fms antibody inhibits lipopolysaccharide-induced osteoclastogenesis in vivo. FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY 64:219-227(2012).
Gorgojo, J; Lamberti, Y; et al. Bordetella parapertussis Survives the Innate Interaction with Human Neutrophils by Impairing Bactericidal Trafficking inside the Cell through a Lipid Raft-Dependent Mechanism Mediated by the Lipopolysaccharide O Antigen. INFECTION AND IMMUNITY 80:4309-4316(2012).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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