Rabbit anti-Human MYL4 monoclonal antibody for WB
MYL4 (Myosin Light Chain 4) is a Protein Coding gene. Diseases associated with MYL4 include congenital disorder of glycosylation, type iid and aortic valve disease 2. Among its related pathways are Cardiac conduction and Aquaporin-mediated transport. GO annotations related to this gene include calcium ion binding and actin monomer binding. An important paralog of this gene is MYL3. Myosin is a hexameric ATPase cellular motor protein. It is composed of two myosin heavy chains, two nonphosphorylatable myosin alkali light chains, and two phosphorylatable myosin regulatory light chains. This gene encodes a myosin alkali light chain that is found in embryonic muscle and adult atria. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.
Myosin is a hexameric ATPase cellular motor protein. It is composed of two myosin heavy chains, two nonphosphorylatable myosin alkali light chains, and two phosphorylatable myosin regulatory light chains. Myosin Light Chain 4 is a myosin alkali light chain that is found in embryonic muscle and adult atria. Regulatory light chain of myosin. Does not bind calcium. Atrial Light Chain-1 (ALC-1), also known as Essential Light Chain, Atrial is a protein that in humans is encoded by the MYL4 gene. ALC-1 is expressed in fetal cardiac ventricular and fetal skeletal muscle, as well as fetal and adult cardiac atrial tissue. ALC-1 expression is reactivated in human ventricular myocardium in various cardiac muscle diseases, including hypertrophic cardiomyopathy, dilated cardiomyopathy, ischemic cardiomyopathy and congenital heart diseases. ALC-1 is expressed very early in skeletal muscle and cardiac muscle development; two E-boxes and CArG box in the MYL4 promoter region regulate transcription. ALC-1 expression in cardiac ventricles decreases in early postnatal development, but is highly expressed in atria throughout all of adulthood. ALC-1 expression and normal atrial function are essential for embryogenesis, as inactivation of the MYL4 gene was embryonic lethal at ED10. 42501. 5.
Muscle contraction, organism-specific biosystem; Myometrial Relaxation and Contraction Pathways, organism-specific biosystem; Striated Muscle Contraction, organism-specific biosystem; Striated Muscle Contraction, organism-specific biosystem.
Yang, YP; Womack, JE; et al. Construction of a bovine Chromosome 19 linkage map with an interspecies hybrid backcross. MAMMALIAN GENOME 8:262-266(1997).
Werner, P; Raducha, MG; et al. Physical and linkage mapping of human chromosome 17 loci to dog chromosomes 9 and 5. GENOMICS 42:74-82(1997).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.