Anti-MYL4 monoclonal antibody (DMAB35734)

Rabbit anti-Human MYL4 monoclonal antibody for WB Datasheet

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Specifications


Host Species
Rabbit
Clone
FQS6448
Species Reactivity
Human
Conjugate
Unconjugated

Applications


Application Notes
WB: 1:10,000 - 50,000
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
MYL4; myosin, light chain 4, alkali; atrial, embryonic; myosin, light polypeptide 4, alkali; atrial, embryonic; myosin light chain 4
Entrez Gene ID
UniProt ID

Product Background


Gene summary
MYL4 (Myosin Light Chain 4) is a Protein Coding gene. Diseases associated with MYL4 include congenital disorder of glycosylation, type iid and aortic valve disease 2. Among its related pathways are Cardiac conduction and Aquaporin-mediated transport. GO annotations related to this gene include calcium ion binding and actin monomer binding. An important paralog of this gene is MYL3. Myosin is a hexameric ATPase cellular motor protein. It is composed of two myosin heavy chains, two nonphosphorylatable myosin alkali light chains, and two phosphorylatable myosin regulatory light chains. This gene encodes a myosin alkali light chain that is found in embryonic muscle and adult atria. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.
Antigen Description
Myosin is a hexameric ATPase cellular motor protein. It is composed of two myosin heavy chains, two nonphosphorylatable myosin alkali light chains, and two phosphorylatable myosin regulatory light chains. Myosin Light Chain 4 is a myosin alkali light chain that is found in embryonic muscle and adult atria. Regulatory light chain of myosin. Does not bind calcium. Atrial Light Chain-1 (ALC-1), also known as Essential Light Chain, Atrial is a protein that in humans is encoded by the MYL4 gene. ALC-1 is expressed in fetal cardiac ventricular and fetal skeletal muscle, as well as fetal and adult cardiac atrial tissue. ALC-1 expression is reactivated in human ventricular myocardium in various cardiac muscle diseases, including hypertrophic cardiomyopathy, dilated cardiomyopathy, ischemic cardiomyopathy and congenital heart diseases. ALC-1 is expressed very early in skeletal muscle and cardiac muscle development; two E-boxes and CArG box in the MYL4 promoter region regulate transcription. ALC-1 expression in cardiac ventricles decreases in early postnatal development, but is highly expressed in atria throughout all of adulthood. ALC-1 expression and normal atrial function are essential for embryogenesis, as inactivation of the MYL4 gene was embryonic lethal at ED10. 42501. 5.
Pathway
Muscle contraction, organism-specific biosystem; Myometrial Relaxation and Contraction Pathways, organism-specific biosystem; Striated Muscle Contraction, organism-specific biosystem; Striated Muscle Contraction, organism-specific biosystem.

Citations


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References


Yang, YP; Womack, JE; et al. Construction of a bovine Chromosome 19 linkage map with an interspecies hybrid backcross. MAMMALIAN GENOME 8:262-266(1997).
Werner, P; Raducha, MG; et al. Physical and linkage mapping of human chromosome 17 loci to dog chromosomes 9 and 5. GENOMICS 42:74-82(1997).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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