Anti-MYH7 (aa 1-109) polyclonal antibody

Species Reactivity

Human

Immunogen

MYH7 (NP_000248, 1 a.a. ~ 109 a.a) partial recombinant protein with GST tag. The sequence is MGDSEMAVFGAAAPYLRKSEKERLEAQTRPFDLKKDVFVPDDKQEFVKAKIVSREGGKVT AETEYGKTVTVKEDQVMQQNPPKFDKIEDMAMLTFLHEPAVLYNLKDRY

Conjugate

Alternative Names

MYH7; myosin, heavy chain 7, cardiac muscle, beta; CMH1; MPD1; SPMD; SPMM; CMD1S; MYHCB; myosin-7; myHC-beta; myhc-slow; myopathy, distal 1; myosin heavy chain slow isoform; rhabdomyosarcoma antigen MU-RMS-40.7A; myosin heavy chain, cardiac muscle beta is

Entrez Gene ID

UniProt ID

Antigen Description

Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. This gene encodes the beta (or slow) heavy chain subunit of cardiac myosin. It is expressed predominantly in normal human ventricle. It is also expressed in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy.

Pathway

Adrenergic signaling in cardiomyocytes; Dilated cardiomyopathy; Membrane Trafficking; Translocation of GLUT4 to the plasma membrane