Specifications
Species Reactivity
Mouse; Human
Immunogen
Synthetic peptide within Human MYBPC3 aa 188-218 (N terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.Database link: Q14896
Applications
Application Notes
WB: 1/100 - 1/500; IHC-P: 1/10 - 1/50.
Target
Alternative Names
MYBPC3; myosin binding protein C, cardiac; CMH4, myosin binding protein C, cardiac; myosin-binding protein C, cardiac-type; FHC; MYBP C; C-protein, cardiac muscle isoform; myosin-binding protein C, cardiac; CMH4; MYBP-C; DKFZp779E1762;
Product Background
Antigen Description
Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.
Pathway
Dilated cardiomyopathy; Hypertrophic cardiomyopathy (HCM); Muscle contraction; Striated Muscle Contraction;
Citations
Publication ()
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COA
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