Specifications
Species Reactivity
Human; Rat
Immunogen
MTHFD1L (NP_056255, 801 a.a. ~ 899 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Target
Alternative Names
MTHFD1L; methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like; formyltetrahydrofolate synthetase domain containing 1 , FTHFSDC1; monofunctional C1-tetrahydrofolate synthase, mitochondrial; 10 formyl THF synthetase; DKFZP586G1517; FLJ21145; mit
Product Background
Antigen Description
One-carbon substituted forms of tetrahydrofolate (THF) are involved in the de novo synthesis of purines and thymidylate and support cellular methylation reactions through the regeneration of methionine from homocysteine. MTHFD1L is an enzyme involved in THF synthesis in mitochondria (Christensen et al., 2005 [PubMed 15611115]).
Pathway
C1-unit interconversion, eukaryotes, organism-specific biosystem; C1-unit interconversion, eukaryotes, conserved biosystem; Metabolic pathways, organism-specific biosystem; One Carbon Metabolism, organism-specific biosystem; One carbon pool by folate, organism-specific biosystem; One carbon pool by folate, conserved biosystem.
Citations
Publication ()
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COA
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