Anti-MTHFD1 (aa 137-150) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide: RGDLNDCFIPCTPK, corresponding to internal sequence amino acids 137-150 of Human MTHFD1 (NP_005947.2)

Conjugate

Application Notes

Peptide ELISA: Antibody detection limit dilution 1/1000. WB: Use at a concentration of 1 - 3 μg/ml. Detects a band of approximately 110 kDa (predicted molecular weight: 102 kDa).

Alternative Names

MTHFD1; methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase; MTHFC, MTHFD; C-1-tetrahydrofolate synthase, cytoplasmic; C1-THF synthase; cytoplasmic C-1-tetrahydrofolate sy

Entrez Gene ID

UniProt ID

Antigen Description

MTHFD1 (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase) is a protein-coding gene. Diseases associated with MTHFD1 include spina bifida, folate-sensitive, and spina bifida, and among its related super-pathways are glycine biosynthesis I and One carbon pool by folate. GO annotations related to this gene include methylenetetrahydrofolate dehydrogenase (NADP+) activity and formate-tetrahydrofolate ligase activity. An important paralog of this gene is MTHFD1L.

Pathway

C1-unit interconversion, eukaryotes; Metabolic pathways; Metabolism; Metabolism of folate and pterines; Metabolism of vitamins and cofactors; Metabolism of water-soluble vitamins and cofactors;