The Escherichia coli MutHLS system has been highly conserved throughout evolution. The eukaryotic pathway results in a specialization of MutS homologs such as MSH2 that have evolved to play crucial roles in both DNA mismatch repair and meiotic recombination. In Saccharomyces cerevisiae, MSH4 is a meiosis-specific protein that is not involved in mismatch correction. This protein is required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis I.
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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Takamatsu, S; Kato, R; et al. Mismatch DNA recognition protein from an extremely thermophilic bacterium, Thermus thermophilus HB8. NUCLEIC ACIDS RESEARCH 24:640-647(1996).
Hoffman, PD; Wang, HX; et al. Binding of MutS mismatch repair protein to DNA containing UV photoproducts, "mismatched" opposite Watson-Crick and novel nucleotides, in different DNA sequence contexts. DNA REPAIR 4:983-993(2005).
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