MSH2 (AAH21566, 835 a.a. ~ 934 a.a) partial recombinant protein with GST tag. The sequence is NFPKHVIECAKQKALELEEFQYIGESQGYDIMEPAAKKCYLEREQGEKIIQEFLSKVKQM PFTEMSEENITIKLKQLKAEVIAKNNSFVNEIISRIKVTT
Conjugate
Unconjugated
Target
Alternative Names
MSH2; mutS homolog 2; FCC1; COCA1; HNPCC; LCFS2; HNPCC1; DNA mismatch repair protein Msh2; hMSH2; mutS homolog 2, colon cancer, nonpolyposis type 1;
This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene.
Pathway
BRCA1-associated genome surveillance complex (BASC); Colorectal cancer; Direct p53 effectors; Integrated Cancer pathway
Citations
Publication ()
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