Magic™ Anti-MPO monoclonal antibody (DMAB-L21030)

Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Species Reactivity
Human
Conjugate
Unconjugated

Applications


Application Notes
ELISA, WB
We recommend the following for sandwich ELISA (Capture - Detection):
DMAB-L21029 - DMAB-L21030
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
MPO; AFBP; IBP1; PP12; IGF-BP25; hIGFBP-1
Entrez Gene ID
UniProt ID

Product Background


Pathway
C-MYB transcription factor network, organism-specific biosystem; Folate Metabolism, organism-specific biosystem; IL23-mediated signaling events, organism-specific biosystem; Phagosome, organism-specific biosystem; Phagosome, conserved biosystem; Selenium Pathway, organism-specific biosystem; amb2 Integrin signaling, organism-specific biosystem

Citations


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References


Myeloperoxidase and Lysozymes as a Pivotal Hallmark of Immunity Status in Rabbits

ANIMALS

Authors: Hrynkiewicz, Rafal; Bebnowska, Dominika; Niedzwiedzka-Rystwej, Paulina

Simple Summary Rabbit breeding is a very important element in the context of broadly understood industrial breeding, as rabbits are one of the main and most frequently chosen economic directions. Effective rabbit breeding, however, requires full control over the health of these animals, which is particularly related to the orientation regarding their immune status. There are many indicators that can be used to assess the immune system, but the greatest attention should be paid to those that change rapidly over time and reflect the body's first line of defense. Peripheral blood granulocytes contain enzymes with strong antimicrobial properties, the level of which changes as a result of various external factors, e.g., viral infection, which was assessed in this study. The aim of the study was to evaluate the dynamics of myeloperoxidase (MPO) and lysozyme (LZM) in the experimental infection of rabbits with theLagovirus europaeus/GI.1a virus, which is a pathogen causing high mortality, decimating rabbit farms all over the world in a short time. The results obtained in the dynamic system show that the levels of assessed enzymes significantly change in the blood during infection. Assessing the immune system using these indicators could therefore be a potential biomarker for the immune status of rabbits. Infectious diseases, due to their massive scale, are the greatest pain for all rabbit breeders. Viral infections cause enormous economic losses in farms. Treating sick rabbits is very difficult and expensive, so it is very important to prevent disease by vaccinating. In order to successfully fight viral infections, it is important to know about the immune response of an infected animal. The aim of this study was to analyze the immune response mediated by antimicrobial peptides (myeloperoxidase (MPO) and lysozyme (LZM)) in peripheral blood neutrophils and rabbit serum by non-invasive immunological methods. The study was carried out on mixed breed rabbits that were experimentally infected with two strains (Erfurt and Rossi) of theLagovirus europaeus/GI.1a virus. It has been observed that virus infection causes changes in the form of statistically significant increases in the activity of MPO and LZM concentration, while in the case of LZM activity only statistically significant decreases were noted. Additionally, clinical symptoms typical for the course of the disease were noted, and the probability of survival of the animals at 60 h p.i. (post infection) was 30% for the Erfurt strain, and -60% for the Rossi strain. The obtained results of MPO and LZMs suggest that these enzymes, especially MPO, may serve as a prognostic marker of the state of the immune system of rabbits.

A general automatic method for optimal construction of matrix product operators using bipartite graph theory

JOURNAL OF CHEMICAL PHYSICS

Authors: Ren, Jiajun; Li, Weitang; Jiang, Tong; Shuai, Zhigang

Constructing matrix product operators (MPOs) is at the core of the modern density matrix renormalization group (DMRG) and its time dependent formulation. For the DMRG to be conveniently used in different problems described by different Hamiltonians, in this work, we propose a new generic algorithm to construct the MPO of an arbitrary operator with a sum-of-products form based on the bipartite graph theory. We show that the method has the following advantages: (i) it is automatic in that only the definition of the operator is required; (ii) it is symbolic thus free of any numerical error; (iii) the complementary operator technique can be fully employed so that the resulting MPO is globally optimal for any given order of degrees of freedom; and (iv) the symmetry of the system could be fully employed to reduce the dimension of MPO. To demonstrate the effectiveness of the new algorithm, the MPOs of Hamiltonians ranging from the prototypical spin-boson model and the Holstein model to the more complicated ab initio electronic Hamiltonian and the anharmonic vibrational Hamiltonian with the sextic force field are constructed. It is found that for the former three cases, our automatic algorithm can reproduce exactly the same MPOs as the optimally hand-crafted ones already known in the literature.

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