Anti-MLH1 monoclonal antibody, clone 739DU5.7.2

Antibody Isotype

IgG1

Clone

739DU5.7.2

Species Reactivity

Human

Conjugate

Application Notes

WB: 1:100-400

Alternative Names

MLH1; COCA2; DNA mismatch repair protein Mlh1; MutL protein homolog 1

Entrez Gene ID

UniProt ID

Antigen Description

This gene was identified as a locus frequently mutated inhereditary nonpolyposis colon cancer (HNPCC). It is a human homologof the E. coli DNA mismatch repair gene mutL, consistent with thecharacteristic alterations in microsatellite sequences(RER+phenotype) found in HNPCC. Alternative splicing results inmultiple transcript variants encoding distinct isoforms. Additionaltranscript variants have been described, but their full-lengthnatures have not been determined.

Pathway

BRCA1-associated genome surveillance complex (BASC); Colorectal cancer; Direct p53 effectors; Endometrial cancer; Fanconi anemia pathway; Meiosis; Meiotic Recombination; Mismatch repair;