Specifications
Immunogen
Recombinant full length Human Monoacylglycerol Lipase produced in HEK293T cells (NP_009214).
Applications
Application Notes
WB: 1/2000; IHC-P: 1/150; ICC/IF: 1/100; Flow Cyt: 1μg/106 cells;
Target
Alternative Names
MGLL; monoglyceride lipase; HU K5; MGL; monoacylglycerol lipase; lysophospholipase homolog; HUK5; MAGL; HU-K5;
Product Background
Antigen Description
Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (By similarity). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth.
Pathway
Acylglycerol degradation, organism-specific biosystem; Acylglycerol degradation, conserved biosystem; Arachidonate production from DAG, organism-specific biosystem; Effects of PIP2 hydrolysis, organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; Glycerolipid metabolism, organism-specific biosystem;
Citations
Publication ()
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COA
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