Anti-MCM5 monoclonal antibody, clone 4B8

Antibody Isotype

IgM

Clone

4B8

Species Reactivity

Human

Immunogen

MCM5 (AAH00142, 1 a.a. ~ 734 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Conjugate

Alternative Names

MCM5; minichromosome maintenance complex component 5; CDC46, MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) , minichromosome maintenance deficient (S. cerevisiae) 5 (cell division cycle 46); DNA replication licensing f

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. The encoded protein is a member of the MCM family of chromatin-binding proteins and can interact with at least two other members of this family. The encoded protein is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may actively participate in cell cycle regulation.

Pathway

Activation of ATR in response to replication stress, organism-specific biosystem; Activation of the pre-replicative complex, organism-specific biosystem; Assembly of the pre-replicative complex, organism-specific biosystem; Cell Cycle, organism-specific biosystem; Cell Cycle Checkpoints, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; Cell cycle, organism-specific biosystem;