Specifications
Species Reactivity
Mouse; Rat; Human
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding serine 622 of human Tau.
Applications
Application Notes
ICC/IF: 1/100 - 1/500; WB: 1/2000 - 1/10000; Flow Cyt: 1/160 - 1/1000.
Target
Alternative Names
MAPT; microtubule-associated protein tau; DDPAC, MAPTL; FLJ31424; FTDP 17; G protein beta1/gamma2 subunit interacting factor 1; MGC138549; microtubule associated protein tau; isoform 4; MSTD; MTBT1; MTBT2; PPND; tau; TAU; PHF-tau; paired helical filament-
Product Background
Antigen Description
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Pathway
Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Apoptosis, organism-specific biosystem; Apoptotic cleavage of cellular proteins, organism-specific biosystem; Apoptotic executionphase, organism-specific biosystem; Caspase-mediated cleavage of cytoskeletal proteins, organism-specific biosystem; IL-6 Signaling Pathway, organism-specific biosystem;
Citations
Publication ()
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COA
 monoclonal Antibody, clone FQS3500.jpg)
 monoclonal Antibody, clone FQS3407.jpg)
 Antibody_1.gif)
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