Anti-TAB2 monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide of human MAP3K7IP2 is used for rabbit immunization.

Conjugate

Alternative Names

TAB2; TGF-beta activated kinase 1/MAP3K7 binding protein 2; CHTD2; MAP3K7IP2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; TAB-2; TAK1-binding protein 2; TGF-beta-activated kinase 1-binding protein 2; mitogen-activated protein kinase kinase k

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts.

Pathway

Activated TLR4 signalling; Adaptive Immune System; Cytokine Signaling in Immune system; Diurnally regulated genes with circadian orthologs; Downstream TCR signaling; Epstein-Barr virus infection; Epstein-Barr virus infection; ErbB4 signaling events; FCERI mediated NF-kB activation; Fc epsilon receptor (FCERI) signaling; Herpes simplex infection;