This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. [provided by RefSeq, Jul 2008]
Pathway
Adaptive Immune System; Alternative NF-kappaB pathway; Apoptosis; Apoptosis Modulation and Signaling; CD28 co-stimulation; CD28 dependent PI3K/Akt signaling; CD40/CD40L signaling; Costimulation by the CD28 family
Citations
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