General Notes
This product (Catalog No. DPABH-25039) is a rabbit-derived polyclonal antibody raised against human MAP2K4, targeting the amino acid region 70–399 of the protein. It has been affinity purified by Protein A. MAP2K4, also known as mitogen-activated protein kinase kinase 4 (MKK4), is a gene located on human chromosome 17p12 that encodes a dual-specificity protein kinase essential to the mitogen-activated protein kinase (MAPK) signaling cascades. This kinase, often referred to by aliases such as SEK1, JNKK1, or SERK1, integrates multiple biochemical signals through phosphorylation on serine and threonine residues by upstream MAP kinase kinase kinases (MAPKKKs), which enables it to activate downstream MAPKs at threonine and tyrosine residues. Expressed ubiquitously across human tissues, with particularly high levels in the brain and thyroid, MAP2K4 produces multiple isoforms through alternative splicing, enabling its versatile roles in cellular processes.
DPABH-25039 is suitable for use in ELISA (1:4,000–1:8,000), IHC (1:50–1:100), Western blot (WB) (1:1,000–1:4,000) applications.
DPABH-25039 is supplied as a liquid formulation in 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
Alternative Names
MEK 4; MEK4; SAPK kinase 1; JNKK; c-Jun N-terminal kinase kinase 1; SEK1; JNK-activating kinase 1; MAPK/ERK kinase 4; MAPKK 4; SERK1; SKK1; SAPKK-1; SAPK/ERK kinase 1; PRKMK4; MKK4; MAP kinase kinase 4; MAP2K4; Dual specificity mitogen-activated protein kinase kinase 4; SAPKK1; Stress-activated protein kinase kinase 1; JNKK1
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