Anti-MAP2K4 monoclonal antibody, clone 6I5

Antibody Isotype

IgG1

Clone

6I5

Species Reactivity

Human

Immunogen

Recombinant protein corresponding to human MAP2K4.

Conjugate

Application Notes

ELISA (1:10000); WB (1:500-1:2000); Immunohistochemistry (1:200-1:1000); Flow Cytometry (1:200-1:400) & The optimal working dilution should be determined by the end user.

Alternative Names

MAP2K4; mitogen-activated protein kinase kinase 4; SERK1; dual specificity mitogen-activated protein kinase kinase 4; JNKK1; MEK4; MKK4; PRKMK4; MEK 4; MAPKK 4; SAPK kinase 1; MAPK/ERK kinase 4; SAPK/ERK kinase 1; MAP kinase kinase 4; JNK-activated kinase

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver.

Pathway

Activated TLR4 signalling, organism-specific biosystem; Apoptosis, organism-specific biosystem; CD40/CD40L signaling, organism-specific biosystem; CDC42 signaling events, organism-specific biosystem; Cellular roles of Anthrax toxin, organism-specific biosystem; Ceramide signaling pathway, organism-specific biosystem; Chagas disease (American trypanosomiasis), organism-specific biosystem;