Anti-MAF (aa 304-403) polyclonal antibody

Species Reactivity

Human

Immunogen

MAF (NP_005351, 304 a.a. ~ 403 a.a) partial recombinant protein with GST tag. The sequence is SCRFKRVQQRHVLESEKNQLLQQVDHLKQEISRLVRERDAYKEKYEKLVSSGFRENGSSS DNPSSPEFFITEPTRKLEPSVGYATFWKPQHRVLTSVFTK

Conjugate

Alternative Names

MAF; v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog; CCA4; c-MAF; transcription factor Maf; c-maf proto-oncogene; proto-oncogene c-Maf; T lymphocyte c-maf long form; Avian musculoaponeurotic fibrosarcoma (MAF) protooncogene;

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene is a DNA-binding, leucine zipper-containing transcription factor that acts as a homodimer or as a heterodimer. Depending on the binding site and binding partner, the encoded protein can be a transcriptional activator or repressor. This protein plays a role in the regulation of several cellular processes, including embryonic lens fiber cell development, increased T-cell susceptibility to apoptosis, and chondrocyte terminal differentiation. Defects in this gene are a cause of juvenile-onset pulverulent cataract as well as congenital cerulean cataract 4 (CCA4). Two transcript variants encoding different isoforms have been found for this gene.

Pathway

C-MYB transcription factor network; Inflammatory bowel disease (IBD); Keap1-Nrf2 Pathway; Transcriptional misregulation in cancer