Anti-M6PR monoclonal antibody, clone 3H22

Antibody Isotype

IgG2a

Clone

3H22

Species Reactivity

Mouse; Rat; Cow; Human; African green monkey

Conjugate

Application Notes

WB: 5 - 10 μg/ml; ICC/IF: 5 - 10 μg/ml; Flow Cyt: 10μg/10⁶ cells;

Alternative Names

M6PR; mannose-6-phosphate receptor (cation dependent); cation-dependent mannose-6-phosphate receptor; Mr 46,000 Man6PR; CD Man-6-P receptor; small mannose 6-phosphate receptor; 46-kDa mannose 6-phosphate receptor; SMPR; MPR46; CD-MPR; MPR 46; MPR-46; FLJ3

Entrez Gene ID

UniProt ID

Antigen Description

Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.

Pathway

Clathrin derived vesicle budding, organism-specific biosystem; Lysosome, organism-specific biosystem; Lysosome, conserved biosystem; Lysosome Vesicle Biogenesis, organism-specific biosystem; Membrane Trafficking, organism-specific biosystem; Phagosome, organism-specific biosystem; Phagosome, conserved biosystem;