Anti-KLRA3 monoclonal antibody (DCABH-8278)

Armenian Hamster anti-Mouse KLRA3 monoclonal antibody for FC

Specifications


Host Species
Armenian Hamster
Antibody Isotype
IgG
Clone
25C22
Species Reactivity
Mouse
Immunogen
The details of the immunogen for this antibody are not available.
Conjugate
Unconjugated

Applications


Application Notes
Flow Cyt: 1μg/106 cells.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
KLRA3; killer cell lectin-like receptor, subfamily A, member 3; killer cell lectin-like receptor 3; lymphocyte antigen 49c; T-cell surface glycoprotein Ly-49C; natural killer cell-associated antigen 2
Entrez Gene ID
UniProt ID

Product Background


Antigen Description
Ly49C, Ly49F, Ly49H and Ly49I are members of the lectin like homodimeric Ly49 family of cell surface receptors. Mouse Ly49 receptors exhibit allelic specificity for MHC class I Ia molecules and are thought to serve to prevent natural killer (NK) cells from attacking normal cells, while allowing them to attack infected or transformed cells in which class I molecules have been down regulated. These inhibitory receptors are also expressed on a subpopulation of mouse CD8+ T cells.
Pathway
Graft-versus-host disease, organism-specific biosystem; Graft-versus-host disease, conserved biosystem; Natural killer cell mediated cytotoxicity, organism-specific biosystem; Natural killer cell mediated cytotoxicity, conserved biosystem.

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Roda-Navarro, P; Arce, I; et al. Human KLRF1, a novel member of the killer cell lectin-like receptor gene family: molecular characterization, genomic structure, physical mapping to the NK gene complex and expression analysis. EUROPEAN JOURNAL OF IMMUNOLOGY 30:568-576(2000).
Fadl, AA; Galindo, CL; et al. Global transcriptional responses of wild-type Aeromonas hydrophila and its virulence-deficient mutant in a murine model of infection. MICROBIAL PATHOGENESIS 42:193-203(2007).

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