The Low-Density Lipoprotein (LDL) Receptor is a mosaic protein of ~840 amino acids (after removal of signal peptide) that mediates the endocytosis of cholesterol-rich LDL. It is a cell-surface receptor that recognizes the apoprotein B100 which is embedded in the phospholipid outer layer of LDL particles. The receptor also recognizes the apoE protein found in chylomicron remnants and VLDL remnants (IDL). In humans, the LDL receptor protein is encoded by the LDLR gene. It belongs to the Low density lipoprotein receptor gene family.
Pathway
Bile secretion; Chylomicron-mediated lipid transport; Endocytosis; Hepatitis C; LDL-mediated lipid transport; Metabolism of lipids and lipoproteins; Statin Pathway; Toxoplasmosis; Wnt Signaling Pathway and Pluripotency
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