Anti-Latency-Associated Nuclear antigen 2 monoclonal antibody (DMAB8924)
Mouse anti-Herpes virus Latency-Associated Nuclear antigen 2 monoclonal antibody for WB, IF, IP
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Recombinant LANA2 fusion protein
Optimal dilution should be determined by the end user. The following are guidelines only: Immunofluorescence: 2 to 4 3g/ml; Immunoprecipitation: 2 to 4 3g/ml; Western Blot : 2 to 4 3g/ml.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
Latency associated nuclear antigen 2; latency-associated nuclear antigen; LANA2
LANA2 (latency-associated nuclear antigen) is an inhibitor of p53-induced transcription in reporter assays and may be an apoptosis antagonist. It is a nuclear protein associated with Kaposi"s sarcoma-associated herpes virus (KSHV), or human herpes virus 8. It is found in abundance in the nuclei of cultured cells from KSHV-infected hematopoietic tissues, such as PEL (primary effusion lymphoma) and CD (multicentric Castleman"s disease). It does not appear to be expressed in KS (Kaposi"s sarcoma) lesions.
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Tomescu, C; Law, WK; et al. Surface downregulation of major histocompatibility complex class I, PE-CAM, and ICAM-1 following de novo infection of endothelial cells with Kaposi's sarcoma-associated herpesvirus. JOURNAL OF VIROLOGY 77:9669-9684(2003).
Machado, DM; Sumita, LM; et al. Seroprevalence of human herpesvirus 8 infection in children born to HIV-1-infected women in Sao Paulo, Brazil. BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH 38:237-240(2005).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.