Anti-Latency-Associated Nuclear antigen 2 monoclonal antibody (DMAB8924)

Mouse anti-Herpes virus Latency-Associated Nuclear antigen 2 monoclonal antibody for WB, IF, IP Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
DN-B918
Species Reactivity
Herpes virus
Immunogen
Recombinant LANA2 fusion protein
Conjugate
Unconjugated

Applications


Application Notes
Optimal dilution should be determined by the end user. The following are guidelines only: Immunofluorescence: 2 to 4 3g/ml; Immunoprecipitation: 2 to 4 3g/ml; Western Blot : 2 to 4 3g/ml.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
Latency associated nuclear antigen 2; latency-associated nuclear antigen; LANA2

Product Background


Antigen Description
LANA2 (latency-associated nuclear antigen) is an inhibitor of p53-induced transcription in reporter assays and may be an apoptosis antagonist. It is a nuclear protein associated with Kaposi"s sarcoma-associated herpes virus (KSHV), or human herpes virus 8. It is found in abundance in the nuclei of cultured cells from KSHV-infected hematopoietic tissues, such as PEL (primary effusion lymphoma) and CD (multicentric Castleman"s disease). It does not appear to be expressed in KS (Kaposi"s sarcoma) lesions.

Citations


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References


Ortonne, N; Fillet, AM; et al. Cutaneous Destombes-Rosai-Dorfman disease: absence of detection of HHV-6 and HHV-8 in skin. JOURNAL OF CUTANEOUS PATHOLOGY 29:113-118(2002).
Wilkinson, D; Sheldon, J; et al. Prevalence of infection with human herpesvirus 8/Kaposi's sarcoma herpesvirus in rural South Africa. SOUTH AFRICAN MEDICAL JOURNAL 89:554-557(1999).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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