Anti-LYST monoclonal antibody (DCABH-712)

Mouse anti-Human LYST monoclonal antibody for ELISA, sELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2b
Species Reactivity
Human
Immunogen
Recombinant fragment, corresponding to amino acids 1-101 of Human LYST with proprietary tag (NP_000072).
Conjugate
Unconjugated

Applications


Application Notes
Sandwich ELISA: 10 μg/ml.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
LYST; lysosomal trafficking regulator; Chediak Higashi syndrome 1 , CHS1; lysosomal-trafficking regulator; CHS; beige homolog
Entrez Gene ID
UniProt ID

Product Background


Gene summary
LYST (Lysosomal Trafficking Regulator) is a Protein Coding gene. Diseases associated with LYST include chediak-higashi syndrome and attenuated chédiak-higashi syndrome. GO annotations related to this gene include binding and phospholipid binding. An important paralog of this gene is WDFY3. This gene encodes a protein that regulates intracellular protein trafficking in endosomes, and may be involved in pigmentation. Mutations in this gene are associated with Chediak-Higashi syndrome, a lysosomal storage disorder. Alternative splicing results in multiple transcript variants, though the full-length nature of some of these variants has not been determined.
Antigen Description
May be required for sorting endosomal resident proteins into late multivesicular endosomes by a mechanism involving microtubules. Chediak-Higashi syndrome (CHS) [MIM:214500]: A rare autosomal recessive disorder characterized by hypopigmentation, severe immunologic deficiency, a bleeding tendency, neurologic abnormalities, abnormal intracellular transport to and from the lysosome, and giant inclusion bodies in a variety of cell types. Most patients die at an early age unless they receive an allogeneic hematopoietic stem cell transplant (SCT). Note=The disease is caused by mutations affecting the gene represented in this entry. The function about LYST antigen include protein binding.

Citations


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References


Faigle, W; Raposo, G; et al. Deficient peptide loading and MHC class II endosomal sorting in a human genetic immunodeficiency disease: the Chediak-Higashi syndrome. JOURNAL OF CELL BIOLOGY 141:1121-1134(1998).
Kisucka, J; Butterfield, CE; et al. Platelets and platelet adhesion support angiogenesis while preventing excessive hemorrhage. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 103:855-860(2006).

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