General Notes
This product (Catalog No. DPABH-20365) is a rabbit-derived polyclonal antibody raised against human LRRC8C, targeting the amino acid region 618–803 of the protein. This antibody exhibits cross-reactivity with Human LRRC8C from mouse and rat. It has been affinity purified by Protein A. LRRC8C (Leucine-rich repeat-containing protein 8C), also known as AD158, is a non-essential component of the volume-regulated anion channel (VRAC, also known as VSOAC channel), which is required to maintain a constant cell volume in response to extracellular or intracellular permeability changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. The VRAC channel also mediates transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol (PMID:24790029; 26824658; 28193731).
DPABH-20365 is suitable for use in Western blot (WB) (1:500–1:2,000), IHC (1:50–1:500), IF/ICC (1:50–1:500) applications.
DPABH-20365 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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