Anti-LOXL3 (aa 171-270) polyclonal antibody

Species Reactivity

Human

Immunogen

LOXL3 (NP_115992, 171 a.a. ~ 270 a.a) partial recombinant protein with GST tag. The sequence is IRPAVGWGRRPLPVTEGLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLGFPSEKRVNAAFY RLLAQRQQHSFGLHGVACVGTEAHLSLCSLEFYRANDTAR

Conjugate

Alternative Names

LOXL3; lysyl oxidase-like 3; LOXL; lysyl oxidase homolog 3; lysyl oxidase-like protein 3;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. Alternatively spliced transcript variants of this gene have been reported but their full-length nature has not been determined.

Pathway

Assembly of collagen fibrils and other multimeric structures; Crosslinking of collagen fibrils; Extracellular matrix organization;