H3F3C (H3 histone, family 3C) is a protein-coding gene. Diseases associated with H3F3C include corneal granular dystrophy, and lattice corneal dystrophy, and among its related super-pathways are Systemic lupus erythematosus. GO annotations related to this gene include DNA binding and protein heterodimerization activity. An important paralog of this gene is HIST2H3D. Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Hominid-specific H3.5/H3F3C preferentially colocalizes with euchromatin, and it is associated with actively transcribed genes.
Pathway
Alcoholism; Systemic lupus erythematosus; Transcriptional misregulation in cancer;
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