LNPEP (NP_005566, 926 a.a. ~ 1025 a.a) partial recombinant protein with GST tag. The sequence is FIIRTVGRHFPGHLLAWDFVKENWNKLVQKFPLGSYTIQNIVAGSTYLFSTKTHLSEVQA FFENQSEATFRLRCVQEALEVIQLNIQWMEKNLKSLTWWL
This gene encodes a zinc-dependent aminopeptidase that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. The protein can be secreted in maternal serum, reside in intracellular vesicles with the insulin-responsive glucose transporter GLUT4, or form a type II integral membrane glycoprotein. The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4) and is also a receptor for AT4. Alternative splicing results in multiple transcript variants encoding different isoforms.
Pathway
Adaptive Immune System; Antigen processing: Ubiquitination & Class I MHC mediated antigen processing & Endosomal/Vacuolar pathway
Citations
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