LLGL2 (NP_004515, 101 a.a. ~ 199 a.a) partial recombinant protein with GST tag. The sequence is SLKVKGGASELQEDESFTLRGPPGAAPSATQITVVLPHSSCELLYLGTESGNVFVVQLPA FRALEDRTISSDAVLQRLPEEARHRRVFEMVEALQEHPR
Conjugate
Unconjugated
Target
Alternative Names
LLGL2; lethal giant larvae homolog 2 (Drosophila); HGL; LGL2; lethal(2) giant larvae protein homolog 2; human giant larvae homolog;
The lethal (2) giant larvae protein of Drosophila plays a role in asymmetric cell division, epithelial cell polarity, and cell migration. This human gene encodes a protein similar to lethal (2) giant larvae of Drosophila. In fly, the proteins ability to localize cell fate determinants is regulated by the atypical protein kinase C (aPKC). In human, this protein interacts with aPKC-containing complexes and is cortically localized in mitotic cells. Alternative splicing results in multiple transcript variants encoding different isoforms.
Pathway
Hippo signaling pathway.
Citations
Publication ()
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