Anti-KSHV ORF45 Monoclonal antibody (DMAB8601)

Mouse Anti-KSHV ORF45 Monoclonal antibody for WB, IF, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
3E5B6
Species Reactivity
KSHV
Immunogen
Purified recombinant fragment of KSHV ORF45 expressed in E. Coli.
Conjugate
Unconjugated

Target


Alternative Names
HHV8; Human herpes virus 8; Kaposi"s sarcoma herpes virus; KSHV; ORF45

Product Background


Antigen Description
Kaposi"s sarcoma-associated herpesvirus (KSHV) belongs to the gamma-(2)-herpesvirus subfamily and has been closely linked to the Kaposi's sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman's disease. The genome of KSHV is 165-170 kb and contains at least 88 open reading frames. ORF45 protein encoded by an immediate-early gene in the KSHV genome is characterized as a phosphorylated protein, and it is localized in the cytoplasm of infected cells. Studies have shown that ORF45 Protein interacted with cellular IRF-7 and blocked virus-mediated phosphorylation and nuclear translocation of IRF-7. In consequence, ORF45 efficiently inhibited virus-induced production of type I IFN. Zhu et al (2003) reported that the ORF45 Protein was associated with purified virions.

Citations


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References


Zhu, FX; Yuan, Y; et al. The ORF45 protein of Kaposi's sarcoma-associated herpesvirus is associated with purified virions. JOURNAL OF VIROLOGY 77:4221-4230(2003).

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