Kallikreins are a subgroup of serine proteases havingdiverse physiological functions. Growing evidence suggests thatmany kallikreins are implicated in carcinogenesis and some havepotential as novel cancer and other disease biomarkers. This geneis one of the fifteen kallikrein subfamily members located in acluster on chromosome 19. Its protein product is a protease presentin seminal plasma. It is thought to function normally in theliquefaction of seminal coagulum, presumably by hydrolysis of thehigh molecular mass seminal vesicle protein. Serum level of thisprotein, called PSA in the clinical setting, is useful in thediagnosis and monitoring of prostatic carcinoma. Alternate splicingof this gene generates several transcript variants encodingdifferent isoforms.
Pathway
Androgen receptor signaling pathway; Coregulation of Androgen receptor activity; FOXA1 transcription factor network; Metabolism of proteins; Pathways in cancer; Prostate Cancer; Prostate cancer; Regulation of Androgen receptor activity;
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