General Notes
This product (Catalog No. DPABH-25937) is a rabbit-derived polyclonal antibody raised against human KLF6, targeting the amino acid region 6–283 of the protein. This antibody exhibits cross-reactivity with Human KLF6 from mouse and rat. It has been affinity purified by Protein A. KLF6(krupple-like factor 6) is a zinc finger transcription factor and tumor suppressor with biological activities and transcriptional targets in growing range. It is highly expressed in placenta followed by spleen, thymus, prostate, testis, small intestine and colon. One key target gene of KLF6 in endoglin, which is a homodimeric cell membrane glycoprotein and TGF-β auxiliary receptor, owns a pro-angiogenic role in endothelial cells and is also involved in malignant progression. Also KLF6 induces apoptosis in prostate cancer cells through upregulation of ATF3. KLF6 has 3 isoforms with the molecular mass of 32, 31 and 26kDa. KLF6 was normal detected as a 46kDa protein, which is larger than translation product(32kDa), because of post-translational modification including both phosphorylation and glycosylation.
DPABH-25937 is suitable for use in Western blot (WB) (1:1,000–1:5,000), IHC (1:20–1:200) applications.
DPABH-25937 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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