Synthetic peptide within Human KLF10 aa 204-233 (internal sequence) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.Database link: Q13118
Conjugate
Unconjugated
Applications
Application Notes
WB: 1/50 - 1/100; Flow Cyt: 1/10 - 1/50.
Target
Alternative Names
KLF10; Kruppel-like factor 10; TGFB inducible early growth response; TIEG; Krueppel-like factor 10; EGRA; TIEG1; TIEG-1; EGR-alpha; TGFB inducible early growth response; TGFB-inducible early growth response protein 1; transforming growth factor-beta-induc
KLF10 (Krueppel-like factor 10), also known as TIEG1, is a transcription factor that plays a role in the regulation of cell growth. It binds to the consensus sequence 5-GGTGTG-3. KLF10 plays a role in the response to TGFbeta (through the TGFbeta/Smad signalling pathway) and estrogen. In both cases, KLF10 induces or repressed gene transcription to enhance the TGFbeta/Smad signalling pathway, as well as other pathways, to regulate cell proliferation, differentiation and apoptosis. KLF10 has been shown to have a role in skeletal disease (osteopenia/osteoporosis), hypertrophic cardiomyopathy, and breast and prostate cancer.
Citations
Publication ()
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