Anti-KHDC3L polyclonal antibody (DPABH-08563)

Rabbit anti-Human KHDC3L (aa 27-56) polyclonal antibody for WB, FC, IHC-P Datasheet

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Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
Synthetic peptide within Human Ecat1 aa 27-56 (N terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.Database link: Q587J8
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/100 - 1/500. Flow Cyt: 1/10 - 1/50. IHC-P: 1/10 - 1/50.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
KHDC3L; KH domain containing 3-like, subcortical maternal complex member; ECAT1; HYDM2; C6orf221; KHDC3-like protein
Entrez Gene ID
UniProt ID

Product Background


Gene summary
KHDC3L (KH Domain Containing 3 Like, Subcortical Maternal Complex Member) is a Protein Coding gene. Diseases associated with KHDC3L include hydatidiform mole, recurrent, 2 and hydatidiform mole, recurrent, 1. GO annotations related to this gene include RNA binding. An important paralog of this gene is OOEP. The protein encoded by this gene belongs to the KHDC1 family, members of which contain an atypical KH domain that may not bind RNA like canonical KH domains. This gene is specifically expressed in the oocytes, and recent studies suggest that it may function as a regulator of genomic imprinting in the oocyte. Mutations in this gene are associated with recurrent biparental complete hydatidiform mole.
Antigen Description
KHDC3L (KH domain containing 3-like, subcortical maternal complex member) is a protein-coding gene. Diseases associated with KHDC3L include hydatidiform mole, recurrent. An important paralog of this gene is OOEP. Hydatidiform mole, recurrent, 2 (HYDM2) [MIM:614293]: A disorder characterized by excessive trophoblast development that produces a growing mass of tissue inside the uterus at the beginning of a pregnancy. It leads to abnormal pregnancies with no embryo, and cystic degeneration of the chorionic villi. Note=The disease is caused by mutations affecting the gene represented in this entry. The function about KHDC3L antigen include RNA binding.

Citations


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References


Akoury, E; Zhang, L; et al. NLRP7 and KHDC3L, the two maternal-effect proteins responsible for recurrent hydatidiform moles, co-localize to the oocyte cytoskeleton. HUMAN REPRODUCTION 30:159-169(2015).

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