Anti-KEAP1 monoclonal antibody, clone 308DU7.2.7

Name: Anti-KEAP1 monoclonal antibody, clone 308DU7.2.7
SKU: DCABY-1200
Rating: 5 (1 reviews)

Mouse anti-Human KEAP1 monoclonal antibody for WB

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COA

SDS

Datasheet

Summary

Specifications

Antibody Isotype

IgM

Clone

308DU7.2.7

Species Reactivity

Human

Conjugate

Unconjugated

Applications

Application Notes

WB: 1:100

Target

Alternative Names

KEAP1; INRF2; KIAA0132; KLHL19; Kelch-like ECH-associated protein 1; Cytosolic inhibitor of Nrf2; Kelch-like protein 19

Entrez Gene ID

9817

UniProt ID

A0A024R7C0

Product Background

Antigen Description

This gene encodes a protein containing KELCH-1 likedomains, as well as a BTB/POZ domain. Kelch-like ECH-associatedprotein 1 interacts with NF-E2-related factor 2 in aredox-sensitive manner and the dissociation of the proteins in thecytoplasm is followed by transportation of NF-E2-related factor 2to the nucleus. This interaction results in the expression of thecatalytic subunit of gamma-glutamylcysteine synthetase. Twoalternatively spliced transcript variants encoding the same isoformhave been found for this gene.

Pathway

Adaptive Immune System; Antigen processing: Ubiquitination & Proteasome degradation; Class I MHC mediated antigen processing & presentation; Immune System; Keap1-Nrf2 Pathway; Ubiquitin mediated proteolysis

Citations

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Documents

pdf COA

pdf SDS

pdf Datasheet

QA & Reviews

Customer Reviews

References

Nuclear factor erythroid 2 (NF-E2) -related factor 2 (Nrf2) in non -small cell lung cancer

LIFE SCIENCES

Authors: Zeng, Zhi; Wang, Zi-yao; Li, Yu-kun; Ye, Dong-mei; Zeng, Juan; Hu, Jia-li; Chen, Pi-feng; Xiao, Jiao; Zou, Juan; Li, Zhen-hua

Abstract

Immune Checkpoint Inhibitor (ICPI) resistance genes STK11 and KEAP1: A comparative Comprehensive Genomic Profiling (CGP) study

ANNALS OF ONCOLOGY

Authors: Alexander, B.; Sokol, E. S.; Danziger, N. A.; Pavlick, D. C.; Elvin, J.; Killian, J. K.; Lin, D. I.; Williams, E.; Ramkissoon, S.; Severson, E.; Hemmerich, A.; Duncan, D.; Edgerly, C.; Huang, R.; Hiemenz, M.; Reddy, P.; McGregor, K.; Venstrom, J.; Schrock, A. B.; Ross, J. S.

Abstract