Anti-KCNT1 polyclonal antibody (DPABH-06296)

Rabbit anti-Human KCNT1 (C-terminal) polyclonal antibody for IHC-P


Host Species
Antibody Isotype
Species Reactivity
Mouse, Rat, Human
Synthetic peptide derived from the C terminus of Human KCNT1.


Application Notes
IHC-P: 5 μg/ml.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.


Alternative Names
KCNT1; potassium channel, subfamily T, member 1; potassium channel subfamily T member 1; KCa4.1; KIAA1422; SLACK
Entrez Gene ID
UniProt ID

Product Background

Gene summary
KCNT1 (Potassium Sodium-Activated Channel Subfamily T Member 1) is a Protein Coding gene. Diseases associated with KCNT1 include epilepsy, nocturnal frontal lobe, 5 and epileptic encephalopathy, early infantile, 14. Among its related pathways are Hepatic ABC Transporters and Sweet Taste Signaling. GO annotations related to this gene include voltage-gated potassium channel activity and calcium-activated potassium channel activity. An important paralog of this gene is KCNU1. Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a sodium-activated potassium channel subunit which is thought to function in ion conductance and developmental signaling pathways. Mutations in this gene cause the early-onset epileptic disorders, malignant migrating partial seizures of infancy and autosomal dominant nocturnal frontal lobe epilepsy. Alternative splicing results in multiple transcript variants.
Antigen Description
Outwardly rectifying potassium channel subunit that may co-assemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro). Epilepsy, nocturnal frontal lobe, 5 (ENFL5) [MIM:615005]: An autosomal dominant focal epilepsy syndrome characterized by childhood onset of clusters of motor seizures during sleep. Some patients may develop behavioral or psychiatric manifestations and/or intellectual disability. The phenotype is more severe than observed in other genetic forms of nocturnal frontal lobe epilepsy. Note=The disease is caused by mutations affecting the gene represented in this entry. Epileptic encephalopathy, early infantile, 14 (EIEE14) [MIM:614959]: A rare epileptic encephalopathy of infancy that combines pharmacoresistant seizures with developmental delay. This severe neurologic disorder is characterized by onset in the first 6 months of life of refractory focal seizures and arrest of psychomotor development. Ictal EEG shows discharges that arise randomly from various areas of both hemispheres and migrate from one brain region to another. Potassium channel subfamily T, member 1, also known as KCNT1 is a human gene that encodes the KCa4. 1 protein. KCa4. 1 is a member of the calcium-activated potassium channel protein family 0The function about KCNT1 antigen include calcium-activated potassium channel activity; ion channel activity; nucleotide binding; voltage-gated potassium channel activity.


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Qin, LJ; Lv, Y; et al. Meta-analysis of association of common variants in the KCNJ11-ABCC8 region with type 2 diabetes. GENETICS AND MOLECULAR RESEARCH 12:2990-3002(2013).
Chen, XD; Yang, YJ; et al. Several Polymorphisms of KCNQ1 Gene Are Associated with Plasma Lipid Levels in General Chinese Populations. PLOS ONE 7:-(2012).

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