Anti-KCNK10 (full length) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Full length protein corresponding to Human KCNK10 aa 1-543.Sequence: MKFPIETPRKQVNWDPKVAVPAAAPVCQPKSATNGQPPAPAPTPTPRLSI SSRATVVARMEGTSQGGLQTVMKWKTVVAIFVVVVVYLVTGGLVFRALEQ PFESSQKNTIALEKAEFLRDHVCVSPQELETLIQHALDADNAGVSPIGNS SNNSSHWDLGSAFFFAGTVITTIGYGNIAPSTE

Conjugate

Application Notes

WB: 1 μg/ml.

Alternative Names

KCNK10; potassium channel, subfamily K, member 10; potassium channel subfamily K member 10; K2p10.1; TREK 2; TREK2; potassium channel TREK-2; TWIK-related K+ channel 2; TREK-2 K(+) channel subunit; 2P domain potassium channel TREK2; outward rectifying pot

Entrez Gene ID

UniProt ID

Antigen Description

KCNK10 belongs to the two pore domain potassium channel family and is an outward rectifying potassium channel. This channel produces rapidly activating and non-inactivating outward rectifier K(+) currents. It is activated by arachidonic acid and other naturally occurring unsaturated free fatty acids. It is also activated by membrane stretching, intracellular acidification, and general anaesthetics. KCNK10 exists in three named isoforms produced by alternative splicing. Isoform a is abundantly expressed in pancreas and kidney and to a lower level in brain, testis, colon, and small intestine. Isoform b is strongly expressed in kidney, and pancreas. Isoform c is abundantly expressed in brain.

Pathway

Gastric acid secretion; Neuronal System; Potassium Channels; TWIK related potassium channel (TREK); Tandem pore domain potassium channels;